Pulsed-wave low-dose ultrasound hyperthermia selectively enhances nanodrug delivery and improves antitumor efficacy for brain metastasis of breast cancer
نویسندگان
چکیده
منابع مشابه
Short-time focused ultrasound hyperthermia enhances liposomal doxorubicin delivery and antitumor efficacy for brain metastasis of breast cancer
The blood-brain/tumor barrier inhibits the uptake and accumulation of chemotherapeutic drugs. Hyperthermia can enhance the delivery of chemotherapeutic agent into tumors. In this study, we investigated the effects of short-time focused ultrasound (FUS) hyperthermia on the delivery and therapeutic efficacy of pegylated liposomal doxorubicin (PLD) for brain metastasis of breast cancer. Murine bre...
متن کاملCancer metastasis at a glance: A brief view of Breast Cancer Brain Metastasis
Cancer initiation and progression is a challenging scenario through developmental processes, which may be more complicated by occurrence of metastasis. Basically, diverse genetic alterations, including mutations, formation of truncated proteins and related pathways play key roles either in diagnosis or the most influential therapeutic purposes. ...
متن کاملCancer metastasis at a glance: A brief view of Breast Cancer Brain Metastasis
Cancer initiation and progression is a challenging scenario through developmental processes, which may be more complicated by occurrence of metastasis. Basically, diverse genetic alterations, including mutations, formation of truncated proteins and related pathways play key roles either in diagnosis or the most influential therapeutic purposes. ...
متن کاملPulsed electromagnetic field at frequency and intensity resembling potassium ion cyclotron resonance selectively impairs breast cancer cell through apoptosis
Introduction: Breast cancer (BC) is the most common women cancer worldwide. Radiotherapy and chemotherapy are the two common treatment options but these techniques suffer low selectivity and adverse effects on surrounding normal tissues. Non- ionizing pulsed electromagnetic fields (PEMFs) in ultra-narrow band frequency and intensity have shown anticancer effects. Changing potas...
متن کاملPulsed High-Intensity Focused Ultrasound Enhances Delivery of Doxorubicin in a Preclinical Model of Pancreatic Cancer.
Pancreatic cancer is characterized by extensive stromal desmoplasia, which decreases blood perfusion and impedes chemotherapy delivery. Breaking the stromal barrier could both increase perfusion and permeabilize the tumor, enhancing chemotherapy penetration. Mechanical disruption of the stroma can be achieved using ultrasound-induced bubble activity-cavitation. Cavitation is also known to resul...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Ultrasonics Sonochemistry
سال: 2017
ISSN: 1350-4177
DOI: 10.1016/j.ultsonch.2016.11.033